Please follow the instruction bellow:
I have written a plan about what I would like to write (page 2,3) about ‘microRNA in breast cancer’ could you please to follow it.
1- As paraphrasing is not allowed in any academic writing so please be sure to rewrite (paraphrase) ALL sentences using clear academic words and keep it in a very high academic standard level.
2- It’s very important to use as more as possible of references to confirm each study.
3- Support all studies with a different scientific sources (references) (try not to include websites as its not allowed to use it in an academic writing) and use the latest published if its possible.
4- Don’t use one source for one study or for one section please support each study “section’ with a number of references.
5- It’s very important to KEEP sentences meaning and make it extremely nicely and clearly written.
6- I included the information about plan contents and put my instruction under each head title ‘so please follow it ’
7- Use Scientific and Academic words as this part of PHD thesis.
So please be careful with my instruction above and avoid plagiarism
It’s very important here to follow my plan; and to correlate the information about MicroRNA with BREAST CANCER, as it’s my field of study.
• The role of microRNA in breast cancer
1-MicroRNA as oncomires
2-MicroRNA as tumor suppressors
Support those roles in breast cancer by including list of mirs incorporated and at which study (supported with a number of references)
• MicroRNA as biomarkers in breast cancer
1-Diagnostic biomarkers
2-Prognostic biomarkers
3-Predictive biomarkers
Write in brief about each type “definition ” and confirm each biomarkers type with examples from different references if possible.
• Methods of microRNA profiling
Write clearly from different articles about the most important techniques used for mir expression profiling.
• MicroRNA expression in breast cancer
At this section I would like to write about 25 and write about All mentioned mirs in the Table below and the information should include the following:
1-Chromosome location.
2-Association with ‘breast cancer’ and ‘other cancer if possible’
Including its role in breast cancer either function as (tumour suppressors) or (oncogene) very important.
8- Examples about studies conducted about each miroRNA (below) in breast cancer and number and type (ex: blood plasma, cells, serum) of samples included in a specific study (its very important to use as more as possible of references to confirm the role of each mirs)
9- If any of the MiroRNA in the table below are not exist in any literature could you please to mention about it at the end of this assay as a limited studies conducted about this microRNA.
List of miRNA in this study:
miRNA
hsa-miR-15b-000390
hsa-miR-20a-000580
hsa-miR-21-000397
hsa-miR-22-000398
hsa-miR-26a-000405
hsa-let-7a-000377
hsa-let-7f-000382
hsa-miR-27a-000408
hsa-miR-27b-000409
hsa-miR-34a-000426
hsa-miR-130a-000454
hsa-miR-130b-000456
hsa-miR-142-5p-002248
hsa-miR-221-000524
hsa-miR-324-3p-002161
hsa-miR-338-3p-002252
hsa-miR-361-000554
mmu-miR-374-5p-001319
hsa-miR-23b-000400
hsa-miR-26b-000407
hsa-miR-195-000494
hsa-miR-181a-000480
hsa-miR-100-000437
hsa-miR-511-001111
hsa-miR-143-002249
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